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pharmacotherapeutic category:
analgesics and antipyretics.
active ingredients:
paracetamolo.
Excipients:
tablets: microcrystalline cellulose, poverty, sodium croscarMellosa, magnesium stearate, precipitated silica.
effervescent granulate: malt itolo , Mannitolo, sodium bicarbonate, anhydrous citric acid, aroma agrum i, aspartame, sodium documentary.
syrup: saccharose, sodium citrate, cute sodium, methyl parahydroxybenzoate, potassium sorbato, macrogol 6000, acid Citric monohydrate, strawberry aroma, mandarin aroma, purified water.
sugar -free syrup: macrogol, glycerol, sorbitol, xil itolo, sodium citrate, xantan rubber, citric acid, arro But mandarin, p otassio sorbato, methyl parahydroxybenzoate, strawberry aroma, sucralose, purified water.
oral drops: propylene glycol, macrogol 6000, sor bitter, sodium saccarina, aroma vanilla citrus, propyle galland, Dear Mello (E150A), Sodium Ededato, purified water.
Suppository: Solid Synthetic Glycerides.
Indications:
as antipyretic: symptomatic treatment feverish concentrations such as influence, exanthematic diseases, acute affections of the respiratory tract, etc.
as analgesic: headache, neuralgia, Mialgie and on three painful medium entities, of various origins.
contraindications/ESCONDARI:
hypersensitivity ' to paracetamol or any of the excipients; patients with severe hemolytic anemia; severe entep enpococ entep.
dosage:
tablet 500 mg.
children of Weight between 21 and 25 kg: half set it at a time, to be repeated if necessary after 4 hours, without exceeding 6 administrations per day (3 tablets).
children of weight includes or between 26 and 40 kg: 1 tablet at a time, to be repeated if necessary I give 6 hours, without exceeding the 4 administrations per day.
children of weight between 41 and 50 kg: 1 tablet at time, to be repeated if you cease after 4 hours, without exceeding 6 administrations per day.
children of weight higher than 50 kg: 1 tablet at a time, to be repeated if necessary after 4 hours, Without exceeding 6 administrations to Gior no.
adults: 1 tablet at a time, to be repeated if necessary after 4 or king, without exceeding 6 administrations per day.
in the case of severe pain or high fever, 2 500 mg tablets to be repeated if necessary after no n less than 4 hours.
effervescent granulate 500 mg: dissolve the effervescent granulate in a glass of water.
children of weight between 26 and 40 kg: 1 sachet at a time, to be repeated if necessary I give 6 hours, without exceeding 4 administrations per day. Repeat if you need Ssario after 4 hours, without exceeding 6 administrations per day.
boys weighing more than 50 kg: 1 sachet at a time, to be repeated if n essario after 4 hours, without exceeding The 6 administrations per day.
adults: 1 sachet at a time, to be repeated if necessary after 4 hours, if you do not exceed 6 administrations per day.
In the case of severe pain or high fever, 2 500 mg sachets to be repeated if necessary after no less than 4 hours.
effervescent granulate 125 mg: dissolve the granulat or effervescent in a glass of Water.
children of weight between 7 and 10 kg: 1 Packet at a time, to be repeated if necessary after 6 hours, without exceeding 4 administrations per day.
children of weight between 11 and 12 kg: 1 sachet at a time, to be repeated if necessary do Po 4 hours, without exceeding 6 administrations per day.
children of weight between 13 and 20 kg: 2 sachets at a time, to be repeated if necessary after 6 hours, without exceeding 4 administrations per day.
children of weight between 21 and 25 kg: 2 sachets at a time (corresponding bodies to 250 mg of paracetamol), to be repeated if necessary after 4 hours, without exceeding 6 Administrations per day.
syrup (with and without sugar): the package is annexed a glass-dostor with farm levels of levels corresponding to the capacity of 5 ml, 7.5 ml, 10 ml, 15 ml and 20 ml.
children of weight between 7 and 10 kg: 5 ml all time (corresponding to 120 mg of paracetamol), to be repeated if necessary after 6 hours, without exceeding 4 sums nistations per day.
children of weight between 11 and 12 kg: 5 ml at a time (corresponding to 120 mg of paracetamol), to be repeated if necessary after 4 hours, without exceeding the 6 administrations per day.
children of weight between 13 and 20 kg: 7.5-10 ml at a time (corresponding to 1 80 and 240 mg of paracetamol), to be repeated if necessary after 6 hours , if you do not exceed 4 administrations to the.
children of weight between 21 and 25 kg: 10 ml at a time (corresponding to 240 mg of paraceta pier), to be repeated if necessary after 4 hours , without exceeding 6 high nistations per day.
children of weight between 26 and 40 kg: 15-20 ml at a time (corresponding to 360 and 480 mg of parace tamolo respectively), repeat From if necessary after 6 hours, without exceeding the 4 SOM mini -storey per day.
children of weight between 41 and 50 kg: 20 ml at a time (corresponding to 480 mg of paracetamol), from repeat if necessary after 4 hours, without s to hear the 6 administrations per day.
children of weight higher than 50 kg: 20 ml at a time (corresponding to 480 mg of paracetamol), to be repeated if necessary after 4 hours, without exceeding 6 Administrations per day.
adults: 20 ml at a time (c horrifying at 480 mg), to be repeated if necessary after 4 hours, without exceeding 6 administrations per day.
The packaging with a dosage holder holds to facilitate the calculation of the dose of the pr Cicotto according to body weight. Drops or compounds or at 3.1 mg.
children of weight between 3.2 and 6 kg: 14-20 drops at a time (corresponding to 43.4 and 62 mg of Parmes) , to be repeated if Neocetace Ssario after 6 hours, without exceeding 4 administrations per day.
children of weight between 7 and 10 kg: 35-40 drops at a time (correspondence of 108 respectively to 108 , 5 and 124 mg of paracetamol), to be repeated if n Esscessary after 6 hours, without exceeding 4 administrations in the daily o.
children of weight between 11 and 12 kg: 35-40 drops at a time (corresponding to 108.5 and 124 mg of Paracetamol), respectively from an ether if necessary after 4 hours, without exceeding 6 administrations per day.
supposed "babies" (62.5 mg).
supposed "early childhood" (125 mg).
children of weight between 6 and 7 kg: 1 supposed at a time, to be repeated if necessary after 6 hours, without exceeding the 4 Som in the day per day.
children of weight between 7 and 10 kg: 1 supplied at the time, to be repeated if necessary after 4-6 hours, without exceeding and the 5 administrations per day.
supposed "children" (250 mg). Repeat if necessary after 8 hours, without exceeding 3 administration ni per day.
children of weight between 13 and 20 kg: 1 supposed at a time, to be repeated if necessary after 6 hours, without exceed 4 Soms Istrazioni per day.
supposed "children" (500 mg).
children of weight between 21 and 25 kg: 1 supposed to time, to be repeated if necessary after 8 hours, without exceeding 3 administrations per day.
children of weight between 26 and 40 kg: 1 supposed to be, to be repeated if necessary after 6 hours, without exceeding 4 administrations to the daily o.
supposed "adults" (1000 mg).
children of weight between 41 and 50 kg: 1 supposed at a time, to be repeated if necessary after 8 hours, without exceeding 3 administrations per day. supposed at a time, to be repeated if necessary after 6 hours, if you do not exceed 4 administrations per day. Supreme nistations per day.
renal failure: in case of severe renal failure (creatinine clearance of less than 10 ml/min), the int hervall among the administrations must be at least 8 hours.
storage:
tablets, effervescent granulate, syrup and sugar -free syrup, oral drops, solution: no special precaution for the preserves.
Suppository: keep a temperature not exceeding 25 degrees C.
warnings:
In the rare cases of allergic reactions, the administration must be suspended and suitable treatment must be established.
Use caution in CAS or chronic alcoholism, excessive intake of alc ool (3 or more alcoholic beverages per day), anorexia, bulimia or SSIA cache, chronic malnutrition (low reserves of liver glutathione) disi entrance, hypovolemia.
in case of protracted use, it is advisable to use the liver and renal function and the blood crashes.
During treatment with paracetamol before taking any other drug with trella that does not contain the same active ingredient, since the paretamol pa it is taken in high doses, serious adverse ions can occur.
> The Drops Drops, Solution contains: Sorbitol and Glycol and Propi Lenico.
The drug contains: Saccarosio.
The drug syrup and "sugar -free" syrup contains: methyl parahydroxybenzo ato.
The drug without sugar without sugar contains: Sorbitolo.
effervescent granulate 125 mg contains: aspartame; Maltitolo; 3,07 mmoli of so God per sachet.
effervescent granulate 500 mg contains: aspartame; m altitude; 12.3 sodium mmoli per sachet.
interactions:
The oral absorption of paracetamol depends on the speed of the gastric emptying.
therefore, the concomitant administration of drugs that slow down (e.g. anticholinergic, opioids) or increase anus (e.g.
procinetics) the speed of the Gastric emptying can probably be one or an increase in product biodysp of the product.
concomitant administration of Colestira Mina reduces the absorption of paracetamol.
l Contemporary intake to paracetamol and chloramfenicolo can induce an increase in the emivit a of chloramfenicolo, with the risk of raising its toxicity.
concomitant use of paracetamol (4 g per day for at least 4 days) with oral ncoagulants can induce light variations in the values of INR.
in these cases it must be conducted in a more frequent monitoring of the values of INR during use concomita nte and after its interruption.
use with extreme caution and under strict control during chronic treatment with drugs that can induction of liver live nosigenases or in case of exposure to substances that can a This effect (for example rifampicin, cimetidine, antiepileptics such as glutimmide, phenobarbital, carbamazepine).
the same is true in cases of ethism and in patients treated with Zidovudine.
The administration of paracetamol can interfere with the determination of the Cemia (through the method of phosphotong acid) and with that of blood sugar (through the method of function-oxidase-peroxidase).
indulgeted effects:
below are the undesirable effects of paracetamol or ganized according to the systemic and organic Meddra classification.
Sufficient data are not available to establish the frequency of the singles listed effects.
System pathologies But emolinfopoietic: trombocitis openia, leukopenia, anemia, agranulocytosis.
unchanged disorders: hypersensitivity reactions (urticaria, edema of the larynx, angioedema, anafilactic shock).
Pathologies of the nervous system: vertigin.
gastrointestinal pathologies: gastrointestinal reaction.
hepatobiliary pathologies: abnormal liver function, hepatitis.
pathologies of the skin and subcutaneous tissue: Erythema Multiform, ST Evens Johnson syndrome, epidermal necrolysis, rash.
kidney and urinary pathologies: acute renal failure, International nephritis, hematuria, anuria.
pregnancy and breastfeeding:
Despite clinical studies in pregnant or breastfeeding patients do not have highlighted particular contraindications to the use of paracetamol or nor caused unwanted effects to be borne by the mother or BA or, it is recommended to administer the product only in cases of actual need.
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