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Zerinol flon 20 effervescent tablets with vitamin C

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Zerinol flon 20 effervescent tablets with vitamin C

illustrative leaflet aifa

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active ingredients

paracetamol, malicious chlorfenamine, ascorbic acid (vitamin C).


Anhydrous citric acid, sodium bicarbonate, sodium carbonate, sorbitol, poveon, dimeticone, aspartame, orange aroma, lemon aroma.


treatment of the symptoms of influence and cooling in adults.


hypersensitivity to paracetamol, chlorfenamine or ascorbic acid, to any of the excipients or other substances strictly related from a chemical point of view, in particular antihistamines of stru chemical ture similar to chlorfenamine; pregnancy and breastfeeding; Patients with manifest insufficiency of energy-6-phosphate of ASI hydrogen and patients with severe hemolytic anemia; severe hepatocellular insufficiency (Child-Pugh C); Glaucoma, prostate hypertrophy, obstruction of the bladder neck, pyloric and duodenal stenosis or other traits of the gastrointestinal and urogenital system, due to the ancient effects; Patients in treatment with monoamine oxidase inhibitors (ima) or in the two following weeks of treatment.


adults: 1 effervescent tablet twice a day.
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Pediatric population: security and effectiveness in patients of age of less than 18 years has not been established.

The effervescent tablet must be dissolved in about half a glass of water.

The medicine must be taken after meals. Duration of the treatment: patients should be warned to contact the doctor if the fever persists or symptoms do not improve after 3 days of treatment. at 25 degrees C.


do not administer for over 3 consecutive days without going the doctor.

if the fever persists for more than three days or if the symptoms do not improve and others appear within t re days or are accompanied by fever, exanthema, excessive quantity of mucus and persistent cough, seek the doctor before continuing the high traction.

paracetamolo: during the treatment check that it is not taken at the same time No other medicine containing paracetamol, since if the paracetamol is taken at high doses, you can not check serious adverse reactions.

invite the patient to contact and any doctor before associating other drug.

doses or prolonged of the product can raise anpatopathy at risk and alter the kidney and the blood even serious.

in case of hypersensitivity reactions 'Al Paracetamolo (Ads.S.Shock an afilactic), the treatment must be interrupted and the necessary medical measures must be implemented in the signs and symptoms. secondary reactions very variable from subject to subject and from compound to compound.

The most frequent secondary effect is sedation that can manifest itself with sleepiness; Of this those who must warn that can lead vehicles or wait for operations that require integrity of the degree of vigilance.

ascorbic acid: ascorbic acid (vitamin C) must be used with caution From subjects who suffer, or have had a past with nefrolithiasis (renal calculation) and by those from the deficit of G6PD (glucose-6-phosphatehydehydenase, emocromatosis, thalassemia or sideroblastic anemia.

patient with Renal or hepatic insufficiency: administering with caution in subjects with renal or liver failure.

elderly: particulartenance must be placed in the relative to the dose in the elderly for their greater sensitivity towards the drug.

In elderly patients in treatment with antihistamine, they can occur with greater probability and effects such as dizziness, sedation, confusion and hypotension.

elderly patients are particularly sensitive to the effects Anticholinergic secondary of the antists Aminics such as dryness of the mouth and retention men urinary men (especially in urinary men). be harmful if suffering from phenylchetonuria (lack of the enzyme Fenilalanin hydroxylase).

patients with rare hereditary problems of fructose intolerance should not take this medicine.

< p> A fragrant effervescent tablet contains 14.83 mmol of sodium.

to be taken into consideration in patients with reduced renal function or following a low sodium diet.
< /p>


paracetamol: use with extreme caution and under strict control during chronic treatment with drugs that can treatment the induction of liver monoxygnais or in the event of exposure to which may have this effect (for example rifampicin, cimetidine, in ntiepileptics such as glutetimmide, phenobarbital, carbam azepine).

normally harmless doses of paracetamol can cause liver damage if taken together with these drugs. Alcohol abuse.

The usual ingestion of anticonvulsant drugs or oral contraceptives can, with an enzymatic induction mechanism, favors the metabolism of paracetamol.

> The use of the product is not recommended if the patient is in trat tamento with anti -inflammatory. The clearance of the paracetamol of a factor of approximately 2.

therefore, dose of paracetamol must be reduced, if administered in association with probenecid.

the cholestiramine reduces the absorption of paracetamol if administered within 1 h from the intake of paracetamol.

The clinical relevance of the interactions between the paras is not yet possible Cetamolo and oral anticoagulants.

therefore, prolonged use of paracetamol in patients in treatment with anticoagulants now is advisable to them only under medical supervision.

The Paracetamol Association with chloramfenicolo can prolong the half -life of chloramfeniculus, increasing the risk of toxicity. The number of leukocytes (neutropenia).

therefore, the medicine should be taken together with Zidovudine only under the doctor's control.

medicines that slow down the emptying gastric, such as the propantine, consequent the speed of the absorption of the paracetamol and delay the onset of the effect. an increase in speed of absorption.

interference with laboratory exams: administration One of Paracetamol can interfere with the termination of uricemia (through the method of phosphotong acid) and with that of blood sugar (through the health method- or ssidase-peroxidase).

Maleato chlorfena : not these should be taken at the same time other substances with anticholinergic action, since they can influence significant. Two weeks following this treatment then that these can prolong and intensify the ancient and depressive effects of the central nervous system (Snc) of malicious chlorfenamine.

The product can interact with alcohol, antidepressant Tric Iclici , neuroleptics or other depressive action drugs on the central nervous system such as barbiturates, sedatives, tranquilizers, hypnotic. Hument of the sedative effect.

like all preparations containing antihistamine, can mask the first signs of ototoxicity of certain the antibiotic product.

chlorfenamine It inhibits metabolism or phenytoin and can obtain toxicity from phenytoin.

ascorbic acid: ascorbic acid (vitamin C) reduces amphetamine levels for inhibition of gastrointestinal absorption.

Vitamin C increases the bioavailability of iron for chelation with deferoxamine.

estrogen can increase the elimination of vitamin C.

Indested effects

following use, the desired effects can be verified below.

The frequency of these unwanted effects cannot be defined Based on the available data.

pathologies of the emolinfopoietic system: trombocytopenia, leukopenia, anemia, agranuloci tosi, pantchopenia.

disorders of the immune system: reaction I of hypersensitivity such as Angioedama, edema of the larynx, anaphylactic shock.

pathologies of the nervous system: sleepiness, asthenia, dizziness, headache, incapacit concentration.

< p> eye pathologies: blurred vision.

respiratory, chest and mediastinic pathologies: thickening of bronchial secretions.

gastrointestinal pathologies: dryness of the jaws, nausea.

hepatobiliary pathologies: alterations of the hepatic and hepatitis functionality.

pathologies of the skin and subcutaneous tissue: with the use of paracetamol they were Report of skin reactions of various types and gravity including cases of urticaria, erythema multiforme, very rare ASI of serious reactions such as Stevens-Johnson (SJS) syndrome, toxic epidermal necrolysis (Ten) and generalized acute exanthematical pustolosis (AGEP).


Renal and urinary pathologies: Renal alterations (acute insufficiency, nephritis in you Rstizia, hematuria, anuria), urinary retention.

The reporting of elle suspected adverse reactions that occurs after the authorization of the medicine is important, as it allows continuous monitoring of the benefit relationship /Risk of the medicine.

pregnancy and breastfeeding

The drug is contraindicated during pregnancy and breastfeeding.

are not Studies were conducted to evaluate the effects on fertility in humans.

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